Dosing guidance for IV colistin in critically ill patients

Loading dose = [Css,avg target (mg/L) × 2.0 × ideal body weight (kg)* ]


Ideal body weight (IBW) in (kg)

Males: IBW = 50 kg + 2.3 kg for each inch over 5 feet.
Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 feet.^

Gender:  
Height:  

Loading Dose = 2 x 2.0 x Kg

Loading Dose

In mg *
In mIU *
Reference

^ Deryke CA, Crawford AJ, Uddin N and Wallace MR. Colistin dosing and nephrotoxicity in a large community teaching hospital. Antimicrob Agents Chemother. 2010;54(10):4503-4505.

* Nation R, Garonzik S, Thamlikitkul V, Giamarellos-Bourboulis E, Forrest A, Paterson D, et al. Dosing guidance for intravenous colistin in critically-ill patients. Clin Infect Dis. 2017;64(5):565-571.

(Kg)

Serum creatinine from Lab report

Cr Cl

$,&

Daily Dose

*

Table of Daily Doses of Colistimethate for a Desired Target colistin Css,avg of 2 mg/L for Narrow Windows of Creatinine Clearance *

CrCl CBA mg/d MIU/d
0 (RRT) 130 3.95
5 to < 10 145 4.4
10 to < 20 160 4.85
20 to < 30 175 5.3
30 to < 40 195 5.9
40 to < 50 220 6.65
50 to < 60 245 7.4
60 to < 70 275 8.35
70 to < 80 300 9
80 to < 90 340 10.3
> 90 360 10.9
Reference
  • $ Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31–41.
  • & Available from: https://www.kidney.org/professionals/KDOQI/gfr_calculatorCoc. As accessed on 30th August, 2019.
  • * Nation R, Garonzik S, Thamlikitkul V, Giamarellos-Bourboulis E, Forrest A, Paterson D, et al. Dosing guidance for intravenous colistin in critically-ill patients. Clin Infect Dis. 2017;64(5):565-571.